Biologists Unravel Drug-Resistance Mechanism In Tumor Cells
About half of all tumors are missing a gene called p53, which helps healthy cells prevent genetic mutations. Many of these tumors develop resistance to chemotherapy drugs that kill cells by damaging t...
Elephants' Low Cancer Rates Explained
Elephants have enhanced defences against cancer that can prevent tumours forming, say scientists. They were trying to explain why the animals have lower levels of cancer than would be expected by thei...
Biologists Unravel Drug-Resistance Mechanism In Tumor Cells
About half of all tumors are missing a gene called p53, which helps healthy cells prevent genetic mutations. Many of these tumors develop resistance to chemotherapy drugs that kill cells by damaging t...
Telomeric repeat-containing RNAs
Telomeric repeat-containing RNA (TERRA)is a long non-coding RNA that forms integral part of telomeric heterochromatin along with the telomeric binding proteins. It plays a key role in maintaining the ...
TERF1
Telomeric repeat-binding factor 1 is a protein that in humans is encoded by the TERF1 gene.
This gene encodes a telomere specific protein which is a component of the shelterin nucleoprotein comple...
TERF1 - Wikipedia
BAG1
BAG family molecular chaperone regulator 1 is a protein that in humans is encoded by the BAG1 gene.
The oncogene BCL2 is a membrane protein that blocks a step in a pathway leading to apoptosis or ...
BAG1 - Wikipedia
Elastin
Elastin is a highly elastic protein in connective tissue and allows many tissues in the body to resume their shape after stretching or contracting. Elastin helps skin to return to its original positio...
POT1
Protection of telomeres protein 1 is a protein that in humans is encoded by the POT1 gene.
This gene is a member of the telombin family and encodes a nuclear protein involved in telomere maintenan...
POT1 - Wikipedia
P53
Tumor proteins p53, also known as p53, cellular tumor antigen p53 (UniProt name), phosphoprotein p53, tumor suppressor p53, antigen NY-CO-13, or transformation-related protein 53 (TRP53), are encoded...
P53 - Wikipedia
RIF1
Telomere-associated protein RIF1 is a protein that in humans is encoded by the RIF1 gene.RIF1 and RIF2 cap the chromosome ends (telomeres).
RIF1 - Wikipedia
ID1
DNA-binding protein inhibitor ID-1 is a protein that in humans is encoded by the ID1 gene.
The protein encoded by this gene is a helix-loop-helix (HLH) protein that can form heterodimers with memb...
ID1 - Wikipedia
TCF7L1
transcription factor 7-like 1 (T-cell specific, HMG-box), also known as TCF7L1, is a human gene.This gene encodes a member of the T cell factor/lymphoid enhancer factor family of transcription factor...
Daf-2
The DAF-2 gene encodes for the insulin-like growth factor 1 (IGF-1) receptor in the worm Caenorhabditis elegans. DAF-2 is part of the first metabolic pathway discovered to regulate the rate of aging....
TELO2
Telomere length regulation protein TEL2 homolog is a protein that in humans is encoded by the TELO2 gene.
TELO2 - Wikipedia
LMNA
Lamin A/C also known as LMNA is a protein that in humans is encoded by the LMNA gene. Lamin A/C belongs to the lamin family of proteins.
The nuclear lamina consist of a two-dimensional matrix of p...
LMNA - Wikipedia
COQ7
The clk-1 (Clock abnormal protein 1) gene encodes an enzyme (demethoxyubiquinone mono-oxygenase) that is necessary for ubiquinone biosynthesis in the worm Caenorhabditis elegans and other eukaryotes. ...
COQ7 - Wikipedia
BAG3
BAG family molecular chaperone regulator 3 is a protein that in humans is encoded by the BAG3 gene. BAG3 is involved in chaperone-assisted selective autophagy (CASA).
BAG proteins compete with Hip...
BAG3 - Wikipedia
JTB (gene)
Protein JTB, also known as the jumping translocation breakpoint protein or prostate androgen-regulated protein (PAR), is a protein that in humans is encoded by the JTB gene.The JTB family of proteins ...
JTB (gene) - Wikipedia
Dyskerin
H/ACA ribonucleoprotein complex subunit 4 is a protein that in humans is encoded by the DKC1 gene.This gene is a member of the H/ACA snoRNPs (small nucleolar ribonucleoproteins) gene family. snoRNPs a...
Dyskerin - Wikipedia
RGN (gene)
Regucalcin is a protein that in humans is encoded by the RGN gene.The protein encoded by this gene is a highly conserved, calcium-binding protein, that is preferentially expressed in the liver and kid...
RGN (gene) - Wikipedia
CYR61
Cysteine-rich angiogenic inducer 61 (CYR61) or CCN family member 1 (CCN1), is a matricellular protein that in humans is encoded by the CYR61 gene.CYR61 is a secreted, extracellular matrix (ECM)-associ...
CYR61 - Wikipedia
ACD (gene)
Adrenocortical dysplasia protein homolog is a protein that in humans is encoded by the ACD gene.
This gene encodes a protein that is involved in telomere function. This protein is one of six core ...
ACD (gene) - Wikipedia
TINF2
TERF1-interacting nuclear factor 2 is a protein that in humans is encoded by the TINF2 gene. TIN2 is a component of the shelterin protein complex found at the end of telomeres.
TINF2 has been show...
TINF2 - Wikipedia
TERF2
Telomeric repeat-binding factor 2 is a protein that is also known as TRF2 and TRBF2. It is in humans encoded by the TERF2 gene.
This gene encodes a telomere specific protein, TERF2, which is a com...
TERF2 - Wikipedia
Sir2
Sir2 (whose homolog in mammals is known as SIRT1, SIR2L1 or Sir2α) was the first gene of the sirtuin genes to be found. It was found in budding yeast, and, since then, members of this highly conserve...