Researchers Make Link Between Genetics, Aging
University of Georgia scientists have shown a hormone instrumental in the aging process is under genetic control, introducing a new pathway by which genetics regulates aging and disease. Previous stud...
Biologists Unravel Drug-Resistance Mechanism In Tumor Cells
About half of all tumors are missing a gene called p53, which helps healthy cells prevent genetic mutations. Many of these tumors develop resistance to chemotherapy drugs that kill cells by damaging t...
Elephants' Low Cancer Rates Explained
Elephants have enhanced defences against cancer that can prevent tumours forming, say scientists. They were trying to explain why the animals have lower levels of cancer than would be expected by thei...
Researchers Make Link Between Genetics, Aging
University of Georgia scientists have shown a hormone instrumental in the aging process is under genetic control, introducing a new pathway by which genetics regulates aging and disease. Previous stud...
TELO2
Telomere length regulation protein TEL2 homolog is a protein that in humans is encoded by the TELO2 gene.
TELO2 - Wikipedia
Biologists Unravel Drug-Resistance Mechanism In Tumor Cells
About half of all tumors are missing a gene called p53, which helps healthy cells prevent genetic mutations. Many of these tumors develop resistance to chemotherapy drugs that kill cells by damaging t...
TERF2
Telomeric repeat-binding factor 2 is a protein that is also known as TRF2 and TRBF2. It is in humans encoded by the TERF2 gene.
This gene encodes a telomere specific protein, TERF2, which is a com...
TERF2 - Wikipedia
P53
Tumor proteins p53, also known as p53, cellular tumor antigen p53 (UniProt name), phosphoprotein p53, tumor suppressor p53, antigen NY-CO-13, or transformation-related protein 53 (TRP53), are encoded...
P53 - Wikipedia
CCL11
C-C motif chemokine 11 also known as eosinophil chemotactic protein and eotaxin-1 is a protein that in humans is encoded by the CCL11 gene. This gene is encoded on three exons and is located on chromo...
CCL11 - Wikipedia
TINF2
TERF1-interacting nuclear factor 2 is a protein that in humans is encoded by the TINF2 gene. TIN2 is a component of the shelterin protein complex found at the end of telomeres.
TINF2 has been show...
TINF2 - Wikipedia
RGN (gene)
Regucalcin is a protein that in humans is encoded by the RGN gene.The protein encoded by this gene is a highly conserved, calcium-binding protein, that is preferentially expressed in the liver and kid...
RGN (gene) - Wikipedia
FGF21
Fibroblast growth factor 21 is a protein that in humans is encoded by the FGF21 gene. The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members poss...
FGF21 - Wikipedia
TA-65
Cycloastragenol is a molecule isolated from various species in the genus Astragalus that is purported to have telomerase activation activity. A single in vitro study done in 2009 led to claims that cy...
Kinase binding protein CGI-121
In molecular biology, the kinase binding protein CGI-121 family of proteins includes the kinase binding protein CGI-121 and its homologues. CGI-121 has been shown to bind to the p53-related protein ki...
Kinase binding protein CGI-121 - Wikipedia
CYR61
Cysteine-rich angiogenic inducer 61 (CYR61) or CCN family member 1 (CCN1), is a matricellular protein that in humans is encoded by the CYR61 gene.CYR61 is a secreted, extracellular matrix (ECM)-associ...
CYR61 - Wikipedia
Daf-16
DAF-16 is the sole ortholog of the FOXO family of transcription factors in the nematode Caenorhabditis elegans. DAF-16 is notable for being the primary transcription factor required for the profound l...
Type XVIII collagen
Type XVIII collagen is a type of collagen which can be cleaved to form endostatin.
Type XVIII collagen - Wikipedia
Type-V collagen
Type-V collagen is a form of fibrillar collagen associated with classical Ehlers-Danlos syndrome.Autoimmunity against type V collagen is associated with lung transplant failure.
Telomeric repeat-containing RNAs
Telomeric repeat-containing RNA (TERRA)is a long non-coding RNA that forms integral part of telomeric heterochromatin along with the telomeric binding proteins. It plays a key role in maintaining the ...
JTB (gene)
Protein JTB, also known as the jumping translocation breakpoint protein or prostate androgen-regulated protein (PAR), is a protein that in humans is encoded by the JTB gene.The JTB family of proteins ...
JTB (gene) - Wikipedia
FOXO3
Forkhead box O3, also known as FOXO3 or FOXO3a, is a human protein encoded by the FOXO3 gene.
FOXO3 belongs to the O subclass of the forkhead family of transcription factors which are characterize...
FOXO3 - Wikipedia
Collagen, type VII, alpha 1
Collagen alpha-1(VII) chain is a protein that in humans is encoded by the COL7A1 gene.
This gene encodes the alpha chain of type VII collagen. The type VII collagen fibril, composed of three ident...
Collagen, type VII, alpha 1 - Wikipedia
Collagen VI
Collagen VI is a form of collagen primarily associated with the extracellular matrix of skeletal muscle.It is associated with the genes COL6A1, COL6A2, COL6A3 and COL6A5.Defects are associated with Be...
Sirtuin
Sirtuin or Sir2 proteins are a class of proteins that possess either mono-ADP-ribosyltransferase, or deacylase activity, including deacetylase, desuccinylase, demalonylase, demyristoylase and depalmit...
Sirtuin - Wikipedia
Telomerase
Telomerase also called telomere terminal transferase is a ribonucleoprotein that is an enzyme that adds DNA sequence repeats (the exact pattern is "TTAGGG" in all vertebrates including humans -- for m...
Telomerase - Wikipedia
BAG3
BAG family molecular chaperone regulator 3 is a protein that in humans is encoded by the BAG3 gene. BAG3 is involved in chaperone-assisted selective autophagy (CASA).
BAG proteins compete with Hip...
BAG3 - Wikipedia
Type-II collagen
Type II collagen is the basis for articular cartilage and hyaline cartilage.It makes up 50% of all protein in cartilage and 85-90% of collagen of articular cartilage.Type II collagen does form fibrils...
Elastin
Elastin is a highly elastic protein in connective tissue and allows many tissues in the body to resume their shape after stretching or contracting. Elastin helps skin to return to its original positio...
Multiplexin
Multiplexin is a class of collagen.
Multiplexin - Wikipedia