Antiandrogen
Antiandrogens, or androgen antagonists, first discovered in the 1960s, prevent androgens from expressing their biological effects on responsive tissues. Antiandrogens alter the androgen pathway by blo...
Antiandrogen - Wikipedia
Mifepristone
Mifepristone (or RU-486) is a synthetic, steroidal antiprogestogen and antiglucocorticoid drug. It is a 19-norsteroid with substitutions at positions C11 and C17 (17β-hydroxy-11β-(4-(dimethylamino)phe...
Mifepristone - Wikipedia
Discovery and development of antiandrogens
In the 1960s, the first antiandrogen, or androgen antagonist, was discovered. Antiandrogens antagonise the androgen receptor (AR) and thereby block the biological effects of testosterone and dihydrote...
Discovery and development of antiandrogens - Wikipedia
Leuprorelin
Leuprorelin (INN) or leuprolide acetate (USAN) is a GnRH analog. Proper Sequence: Pyr-His-Trp-Ser-Tyr-D-Leu-Leu-Arg-Pro-NHEt (Pyr = L-Pyroglutamyl)
Leuprolide acts as an agonist at pituita...
Leuprorelin - Wikipedia
Chlormadinone
Chlormadinone (INN, BAN) is a steroidal progestin which was never marketed. An acylated derivative, chlormadinone acetate, is used clinically used as a pharmaceutical drug.While chlormadinone is somet...
Chlormadinone - Wikipedia
Enzalutamide
Enzalutamide (marketed as Xtandi and formerly known as MDV3100) is an androgen receptor antagonist drug developed by the pharmaceutical company Medivation for the treatment of metastatic castration-re...
Izonsteride
Izonsteride (LY-320,236) is a selective inhibitor of the 5α-reductase, with dual effects on both the type I and type II isoforms of the enzyme. It was under development by Eli Lilly and Company and Fu...
Izonsteride - Wikipedia
Gonadotropin-releasing hormone antagonist
Gonadotrophin-releasing hormone (GnRH) antagonists (receptor blockers) are a class of compounds that are similar in structure to natural GnRH (a hormone made by neurons in the hypothalamus ) but that ...
Valoneic acid dilactone
Valoneic acid dilactone is a hydrolysable tannin that can be isolated from the heartwood of Shorea laeviforia and in oaks species like the North American white oak (Quercus alba) and European red oak...
Valoneic acid dilactone - Wikipedia
Nafarelin
Nafarelin is a gonadotropin-releasing hormone agonist (GnRH agonist). By causing constant stimulation of the pituitary gland, it decreases pituitary secretion of the gonadotropins luteinizing hormone ...
Lapisteride
Lapisteride (INN; CS-891) is a dual inhibitor of both isoforms of the enzyme 5α-reductase. It was under investigation for the treatment of benign prostatic hyperplasia (BPH) and androgenic alopecia, b...
Lapisteride - Wikipedia
5-alpha-reductase inhibitor
5α-reductase inhibitors (5-ARIs) are a class of drugs with antiandrogen effects, used primarily in the treatment of benign prostatic hyperplasia (BPH) and androgenic alopecia.These agents inhibit the ...
5-alpha-reductase inhibitor - Wikipedia
Cyproterone
Cyproterone (INN) is a steroidal antiandrogen that was never marketed. An acylated derivative, cyproterone acetate, is widely used clinically as an antiandrogen and progestin.While cyproterone is som...
Cyproterone - Wikipedia
Flutamide
Flutamide (a.k.a. Eulexin, Flutamin, Cytomid, Chimax, Drogenil) is an oral, non-steroidal antiandrogen drug primarily used to treat prostate cancer. It acts as a silent antagonist of the androgen rece...
Flutamide - Wikipedia
Dutasteride
Dutasteride (Avodart), manufactured by GlaxoSmithKline, is a dual 5-α reductase inhibitor that inhibits conversion of testosterone to dihydrotestosterone (DHT). It is used to treat benign prostatic hy...
Dutasteride - Wikipedia
Finasteride
Finasteride (MK-906, Proscar, and Propecia by Merck, among other generic names) is a drug for the treatment of benign prostatic hyperplasia (BPH) and male pattern baldness (MPB). It is a type II 5α-r...
Finasteride - Wikipedia
Ganirelix
Ganirelix acetate (or diacetate) is an injectable competitive gonadotropin-releasing hormone antagonist (GnRH antagonist). It is primarily used in assisted reproduction to control ovulation. The drug...
Ganirelix - Wikipedia
Degarelix
Degarelix (INN) or degarelix acetate (USAN) (tradename Firmagon) is a hormonal therapy used in the treatment of prostate cancer. During development it was known as FE200486.Testosterone is a male horm...
Degarelix - Wikipedia
Cetrorelix
Cetrorelix acetate (trade name Cetrotide) is an injectable gonadotropin-releasing hormone antagonist (GnRH antagonist). A synthetic decapeptide, it is used to treat hormone-sensitive cancers of the pr...
Cetrorelix - Wikipedia
Bexlosteride
Bexlosteride (LY-191,704) is a potent and noncompetitive inhibitor of the enzyme 5α-reductase related to finasteride and dutasteride. It is selective for the type I isoform of the enzyme. It was never...
Bexlosteride - Wikipedia
Bicalutamide
Bicalutamide (Casodex, Cosudex, Calutide, Kalumid) is an oral non-steroidal antiandrogen used in the treatment of prostate cancer and hirsutism. It was first launched in 1995 as a combination treatmen...
Bicalutamide - Wikipedia
FCE 28260
FCE 28260 is a 5-alpha-reductase inhibitor drug with antiandrogenic activity, which was developed for the treatment of benign prostatic hyperplasia and androgenic (or androgenetic) alopecia in the 19...
FCE 28260 - Wikipedia
Spironolactone
Spironolactone (pronounced /spɪˌrɒnɵˈlæktoʊn/, and commonly shortened simply to "spiro") (INN, BAN, USAN), marketed mainly under the brand name Aldactone in most countries, is a synthetic, steroidal a...
Spironolactone - Wikipedia